hear about neuroendocrine history

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We have recorded podcasts with our doyens to create a repository of memorable interviews.

These doyens have made a significant impact in the field of neuroendocrinology and I’m sure you will enjoy listening to them all.

If you have any suggestions for who you would most like to hear about, do let us know!

We hope you enjoy these podcasts, which are provided by NeuroEndoNow.org under a Creative Commons (CC) license.

Access All Doyens of Neuroendocrinology Podcasts Below

#27 - Prof Sir Steven Bloom

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In this episode Professor Ashley Grossman of the University of Oxford and St Barts in London interviews Prof Sir Steven Bloom, Head of Endocrinology at the Imperial College London. In this podcast, they discuss his career, his life’s work, and expectations for the future.

#25 - Prof Stafford Lightman

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In this episode Professor Rebecca Reynolds interviews Professor Stafford Lightman about his life’s work which has spanned over 30 years.

#24 - Prof Hal Gainer

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In this episode, Professor Gareth Leng talks with another doyen of neuroendocrinology, Professor Hal Gainer about his work over the last 60 years.

#23 - Prof Charles Sawyer

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Professor Robert Millar speaks with Professor Ei Terasawa about the life and work of the doyen on neuroendocrinology, Professor Charles (Tom) Sawyer.

#7 - Ernst Knobil

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In this episode Professor Tony Plant from the University of Pittsburgh discusses Ernst Knobil.

Read more about Ernst Knobil: In Memoriam: Ernst Knobil (1926–2000) Endocrinology. 2001. 142:5047–9.

#3 - Don McCann

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In this episode Professor Robert Millar, Editor-in-Chief of Neuroendocrinology, talks with Professor Sergio Ojeda about Don McCann, one of the leading experts in the field. Prof Ojeda, Senior Scientist at the Oregon National Primate Research Center, did his postdoctoral training in Don McCann’s lab

Access All Our Research Neuroendocrinology Podcasts Below

#37 - 3D Primary Cell Culture: A Novel Preclinical Model For Pancreatic Neuroendocrine Tumors (PanNETs)

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Mr Simon April-Monn, PhD student with Prof Perren and Dr Marinoni at the University of Bern, Switzerland, talks with NEN about their recent publication in Neuroendocrinology.

Interview by Dr Julie Ann Lough

April-Monn S.L., Wiedmer T., Skowronska M., Maire R., Schiavo Lena M., Trippel M., Di Domenico A., Muffatti F., Andreasi V., Capurso G., Doglioni C., Kim-Fuchs C., Gloor B., Zatelli M.C., Partelli S., Falconi M., Perren A., Marinoni I. Neuroendocrinology ePub: 3 April 2020

https://doi.org/10.1159/000507669

 

#36 - GnRH deficiency disease, Kallman Syndrome, and Hypogonadotropic Hypogonadism

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Dr Anna Cariboni from The University of Milan discusses her work on rare GnRH deficiency disease, Kallman Syndrome, and Hypogonadotropic Hypogonadism, using gene knockout studies.

Interview by Dr Julie Ann Lough

Oleari R., Lettieri A., Paganoni A., Zanieri L., Cariboni A. (2018). Semaphorin Signaling in GnRH Neurons: From Development to Disease. Neuroendocrinology.

DOI:10.1159/000495916

#35 - Corticosteroid action in the brain: the potential of selective receptor modulation

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Eva Viho, PhD student at Leiden University Medical Centre, talks to NEN about her recent publication “Corticosteroid action in the brain: the potential of selective receptor modulation.”

Interview by Dr Julie Ann Lough

Viho E.M.G., Buurstede J.C., Mahfouz A., Koorneef L.L., van Weert L.T.C.M., Houtman R., Hunt H.J., Kroon J., Meijer O.C. (2019). Corticosteroid action in the brain: the potential of selective receptor modulation. Neuroendocrinology.

DOI:10.1159/000499659.

#34 - Hot flushes and KNDy ‘candy’ neurons

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Prof Naomi E. Rance, University of Arizona, speaks to NEN at ICN2018 in Toronto, to discusses her body of work on the exciting links between KNDy neurons, menopausal women, and novel approaches to managing hot flushes.

Interview by Dr Julie Ann Lough

#33 - JAK2/STAT5 pathway mediates prolactin-induced apoptosis of lactotropes

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Dr Jimena Ferraris of the Karolinska Institute and the University of Buenos Aires talks with NEN about her recently published work in Neuroendocrinology on the identification of signal transduction pathways that may play a role in the pathogenesis of prolactinomas.

Interview by Dr Julie Ann Lough

de Dios, N., Orrillo, S.J., Irizarri, M., Theas, M., Boutillon, F., Candolfi, M., Seilicovic, A., Goffin, V., Pisera, D., Ferraris, J. (2018). JAK2/STAT5 pathway mediates prolactin-induced apoptosis of lactotropes. Neuroendocrinology

doi: 10.1159/000494975.

#32 - Reducing the heat with neurokinin antagonism: a new non-hormonal approach for treating hot flashes

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Dr Mike Trower of KaNDy Therapeutics talks with NEN at ICN 2018 Toronto about a novel non-hormone approach to reducing hot flashes in women.

Interview by Dr Julie Ann Lough

#31 - Female sexual receptivity depends upon extra-ovarian estradiol synthesis in marmoset monkeys

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Marissa Kraynak of the University of Wisconsin-Madison talks with NEN at ICN 2018 Toronto about ovarian and extra-ovarian estradiol and how they contribute to sexual receptivity regulation in the marmoset monkey.

Interview by Dr Julie Ann Lough

#30 - Novel orally active somotostatin analogs for the treatment of acromegaly

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Dr Stephen Betz of Crinetics Pharmaceuticals talks with NEN at ICN 2018 Toronto about his research on the development of treatments for acromegaly; a condition where a pituitary adenoma causes growth hormone hypersecretion causing gigantism in children and abnormal growths in adults.

Interview by Dr Julie Ann Lough

#29 - Programming of cognitive function by early life stress: a role for nutrition and neuroinflammation

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Dr Aniko Korosi of the University of Amsterdam talks with NEN at ICN 2018 Toronto about the effects of early life stress on metabolism and cognition later in life.

Interview by Dr Julie Ann Lough

#28 - The role of 11beta-HSD2 in glucocorticoid programming of affective and cognitive behaviours

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Dr Megan Holmes of the University of Edinburgh talks to NEN at ICN 2018 Toronto about early life stress and glucocorticoid signaling and the problems it has on longterm outcomes.

Interview by Dr Julie Ann Lough

#26 - Early Life Stress and Long-term Outcomes

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David Walker, a Ph.D. student at The University of St Andrews in Scotland discusses his research looking at the impact of early life stress and long-term outcomes in quails. He also explored the impact of the hormonal stress response later in life.

Interview by Dr Julie Ann Lough

David J. Walker, Cédric Zimmer, Maria Larriva, Susan D. Healy, Karen A. Spencer.

Walker DJ, Spencer KA. Glucocorticoid programming of neuroimmune function. Gen Comp Endocrinol. 2018;256:80-88.

#22 - Long-term Energy Deficit In Mice Causes Long-lasting 1 Hypothalamic Alterations After Recovery

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Dr. Odile Viltart, Associate Professor, Université de Lille, INSERM Department of Psychiatry and Neuroscience, Paris, talks with NEN about her recently published paper in Neuroendocrinology, on the effects of long-term energy deficit and refeeding.

Interview by Dr Julie Ann Lough

Méquinion M, Le Thuc O, Zgheib S, Alexandre D, Chartrel N, Rovère C, Hardouin P, Viltart O, Chauveau C. Long-Term Energy Deficit in Mice Causes Long-Lasting Hypothalamic Alterations after Recovery. Neuroendocrinology. 2017;105(4):372-383.

#21 - Obesity in Labrador Retrievers Linked to POMC Gene Deletion

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Dr. Eleanor Raffen, Wellcome Trust Clinical Research Fellow, University of Cambridge, talks with NEN about her research into obesity and the link with POMC gene deletion.

Interview by Dr Julie Ann Lough

Raffan E, Dennis RJ, O’Donovan CJ, et al. A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metab. 2016;23(5):893-900.

#20 - A Structural Magnetic Resonance Imaging Study in Transgender Persons on Cross-Sex Hormone Therapy

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Sven Mueller from the Department of Experimental Clinical and Health Psychology, Ghent University, talks with NEN about his recent study of neuroanatomical differences in transgender persons after extended cross-sex hormone therapy.

Interview by Dr Julie Ann Lough

Mueller SC, Landré L, Wierckx K, T’Sjoen G. A Structural Magnetic Resonance Imaging Study in Transgender Persons on Cross-Sex Hormone Therapy. Neuroendocrinology. 2017;105(2):123-130.

#19 - IDO predicts death in Neuroendocrine Neoplasia

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Prof. Joerg Schefold of the Bern University Hospital, Switzerland talks to NEN about his research and recent published findings where he investigated the predictive value of IDO activity, tryptophan levels, and downstream catabolites in a neuroendocrine neoplasm patient population.

Interview by Dr Julie Ann Lough

Pschowski R, Pape UF, Fusch G, Fischer C, Jann H, Baur A, Arsenic R, Wiedenmann B, von Haehling S, Pavel M, Schefold JC. Increased Activity of the Immunoregulatory Enzyme Indoleamine-2,3-Dioxygenase with Consecutive Tryptophan Depletion Predicts Death in Patients with Neuroendocrine Neoplasia. Neuroendocrinology. 2017;104(2):135-144.

#18 - Catecholamine metabolism induces mitochondrial DNA deletions and leads to severe adrenal degeneration during aging

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Prof. Rudi Wiesner of the University of Cologne, Germany discusses his recent paper ‘Catecholamine metabolism induces mitochondrial DNA deletions and leads to severe adrenal degeneration during aging’, published in Neuroendocrinology. Prof. Wiesner’s group investigate the mechanisms of mitochondrial loss of function and centres around deciphering this process to be able to slow it down and delay the resulting organ insufficiency. The group’s goal is to understand in detail how mitochondrial damage – in particular damage caused by mitochondrial DNA deletions – arises and how it leads to organ dysfunction by failure of single cells in a tissue.

Interview by Dr Julie Ann Lough

#17 - Social Separation and HPA recovery

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In this episode we are joined by Jack Taylor to talk about his manuscript ‘Reunion behavior after social separation is associated with enhanced HPA recovery in young marmoset monkeys‘ published in Psychoneuroendocrinology. Jack is a doctoral student in the Department of Psychology, University of Nebraska at Omaha.

#16 - Mast cell hyperplasia is associated with aldosterone hypersecretion in a subset of aldosterone-producing adenomas

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In this latest episode we hear from senior author, Hervé Lefebvre, who discusses his recent paper ‘Mast cell hyperplasia is associated with aldosterone hypersecretion in a subset of aldosterone-producing adenomas.‘ Professor Hervé Lefebvre is Head of Department of Endocrinology at University Hospital of Rouen.

#15 - Hypothalamic apelin/reactive oxygen species and hepatic glucose metabolism

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In the latest episode of NeuroEndoNow we hear from first author, Anne Drougard, on her paper ‘Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes.’ Anne completed this work as part of her doctoral research at the French Institute of Health and Medical Research (INSERM).

#14 - Maternal chemical exposure effects on the developing neuroendocrine system: timing of maternal exposure and fetal sex are important

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Dr. Michelle Bellingham of The University of Glasgow talks with NEN about her recent published findings on how the timing of maternal chemical exposure and fetal sex are important for the developing neuroendocrine system.

Interview by Dr Julie Ann Lough

Bellingham, M. , Fowler, P.A., MacDonald, E.S., Mandon-Pepin, B., Cotinot, C., Rhind, S., Sharpe, R.M. and Evans, N.P. (2016) Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep. J Neuroendocrinol, 28(12), 12444.

#13 - Leptin and Taste Buds

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In this latest episode we hear from first author, Tricia Meredith, on her paper ‘Leptin’s Effect on Taste Bud Calcium Responses and Transmitter Secretion‘ published in Chemical Senses. Tricia undertook this work during her postdoctoral work in the lab of Dr Stephen Roper in the Miller School of Medicine, University of Miami

#12 - Voluntary Exercise Adapts the Hypothalamus-pituitary-thyroid Axis in Male Rats

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In this episode we hear from Patricia Joseph-Bravo, on how voluntary exercise can adapt the hypothalamus-pituitary-thyroid axis and the potential implications this has for humans, especially in relation to obesity. This talk focuses on her article ‘Voluntary exercise adapts the hypothalamus-pituitary-thyroid axis in male rats’, published in Endocrinology. Patricia is a Group Head at the National University of Mexico

#11 - Health Outcomes in Acromegaly: Depression and Anxiety – with Victor Geraedts

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In today’s episode we take a look at the health outcomes in Acromegaly and how depression and anxiety are potential targets for improving reduced quality of life in patients. We are joined by Victor Geraedts, a guest researcher at the Max Planck Institue for Psychiatry, Munich and a Medical Intern at Leiden University Medical Center. Victor speaker to us today about his recent paper ‘Health Outcomes in Acromegaly: Depression and Anxiety are Promising Targets for Improving Reduced Quality of Life‘ published in Frontiers in Endocrinology.

#10 - Androgen and Circadian Timing System – with Dr Michael Sellix

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In today’s episode of NeuroEndoNow we hear from Dr Michael Sellix, Assistant Professor in the Department of Medicine, Endocrine/Metabolism at the University of Rochester Medical Centre. Dr Sellix discusses his recent paper ‘Developmental programming by androgen affects the circadian timing system in female mice‘ published in Biology of Reproduction, April 2015.

#9 - Neuronal NOS and Estrogenic-Attenuation of Cannabinoid-Induced Changes in Energy – with Dr Ed Wagner

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In this latest episode of NeuroEndoNow Dr Ed Wagner talks to us about his paper entitled ‘Role of neuronal nitric oxide synthase in the estrogenic attenuation of cannabinoid-induced changes in energy homeostasis’ published in the Journal of Neurophysiology.

#8 - Diet Induced Hyperleptinemia and Ghrelin Resistance

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In this episode of NeuroEndoNow Dr Zane Andrews from Monash University discusses his paper published in Neuroendocrinology on ‘Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice.‘ Dr Andrews studies how the brain regulates food intake and body weight during different metabolic states and in response to different endocrine environments. His particular interest involves mitochondrial mechanisms regulating neuronal metabolism and neuro-protection. He is an expert on the neuroendocrine actions of ghrelin in the brain.

#6 - Masterclass Series in Neuroendocrinology: Neurophysiology of Neuroendocrine Neurons

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In this latest instalment of NeuroEndoNow we learn about the Masterclass Series in Neuroendocrinology, a new series of books covering past and present research in neuroendocrinology. The series, aimed at PhD students and above with an enthusiasm for neuroendocrinology is edited by Dr Bill Armstrong and Dr John Russell. In this podcast Dr Bill Armstrong is joined by Dr Jeffery Tasker, editors of the first book in the series: Neurophysiology of Neuroendocrine Neurons. Together they provide us with insights and highlights from this first instalment in the Masterclass series, as well as give an overview of the series as a whole. If this podcast left you eager for more head over to Wiley where you can get your very own copy of Neurophysiology of Neuroendocrine Neurons. In addition, stay tuned to hear about subsequent volumes from the authors and editors as they are released.

#5 - Diet Induced Hyperleptinemia and Ghrelin Resistance

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In this latest episode of NeuroEndoNow senior author Dr Marcelo Paez-Pereda discusses his recent paper ‘A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.’ published in Nature Medicine. Marcelo Paez-Pereda is an award-winning neuroendocrinologist at the Max Planck Institute of Psychiatry in Munich, Germany. In 2010, he was appointed as Coordinator of Technology Transfer. Previously, he served in the management of Affectis Pharmaceuticals as Director of Drug Discovery. As an expert in neuroendocrine tumors, he conducted research for more than 20 years on the mechanisms that control the secretion of pituitary hormones, in particular in Cushing’s disease. He published numerous book chapters and original articles in prestigious scientific journals.

#4 - The Effect of acyl-ghrelin on neurogenesis and pattern separation

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In this episode of NeuroEndoNow, first author Brianne Kent discusses her recent paper ‘The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation’ published in Psychoneuroendocrinology. Brianne is a final year PhD student working with Dr Lisa Saksida and Professor Tim Bussey at the University of Cambridge. The work presented here was in collaboration with Dr Jeff Davies at Swansea University.

Kent BA, Beynon AL, Hornsby AK, Bekinschtein P, Bussey TJ, Davies JS, Saksida LM. The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation. Psychoneuroendocrinology. 2015 ;51:431-9

#2 - Regulation of Growth Hormone by NPY

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In this podcast we talk with Professor Chen and Dr Steyn on their recent work ‘Actions of NPY, and its Y1 and Y2 Receptors on Pulsatile Growth Hormone Secretion during the Fed and Fasted State’ recently published in Journal of Neuroscience.

#1 - Introducing our new Podcast!

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In our first instalment of the NeuroEndoNow podcast we are joined by Professor Robert Millar and Dr Nick Oswald, Founder of Science Squared Ltd. In this episode you will learn what NeuroEndoNow is all about, and how to get involved. Interested in getting your research highlighted in NeuroEndoNow?